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Chromatography Techniques

Mainframe Technique:
  • HPLC
  • GC
  • UPLC
Sampling Methods:
  • Liquid
  • Headspace
Detection Methods:
  • UV
  • Fluorescent
  • Refractive Index
  • Single Quadrapole Mass Spectrometry
  • Triple Quadrapole Mass Spectrometry
  • Diode-array
  • FID – Flame Ionization Detector

Applications of Chromatography

Chromatography is also used at various stages of a product’s lifecycle:

  • Initial product screening – early stage stability determination and purity of the product
  • Regulatory phase – developing and validating a stability indicating method so that if your product degrades, that your method is capable of detecting degradation. This method will also be used for stability studies to support your submission
  • Post-marketing approval for QC batch release
  • Batch validation to look at consistency between batches
  • Cleaning validation – to ensure that all equipment used in manufacturing is clean before manufacturing a new product to prevent contamination.
  • Method improvement – as technology advances, it is important to keep your methods updated to benefit from further efficiencies, sensitivity and selectivity.

As Mass Spectrometry is used as a detection method, it is typically combined with chromatography to separate the compound prior to detection and quantification. The applications of mass spectrometry at Broughton Laboratories are as follows:

  • E-liquids Analysis
  • Carbonyls analysis in emissions of vaping devices

 

Physical and Chemical Analysis 

Physical and chemical analysis is the fundamental basis of routine identification and quality control testing of product. By conducting this analysis of your product, you are able to determine the quality and consistency of your manufacturing process. Our capabilities at Broughton Laboratories supports a various range of product types from solid dose, liquids, injectables to animal feeds, granules and premixes. Below is a list of techniques we support in-house:

  • Tablet dissolution
  • Tablet disintegration
  • Friability
  • Viscosity
  • UV (Ultraviolet–visible spectroscopy)
  • FTIR (Fourier-transform infrared spectroscopy)
  • TLC (Thin Layer Chromatography)
  • Density testing
  • Refractive index testing
  • Loss on Drying
  • Karl Fisher Titration

Resources

Case Study

Download and read our case study on how we helped our client reduce production downtime through method development and validation of a 'clean in place' procedure which adequately detects traces of flush solvent.

Case Study

Download our case study to read how we helped our client maintain regulatory compliance and extend product shelf-life through our method development, validation and stability management service.

 

Infographic

Wondering how we can help on your drug development pathway? Download our infographic to see where our services can support you from product concept to commercialisation.